Researchers developed a novel peptide, KS-133, to target cognitive dysfunction in schizophrenia. By using a brain-targeting peptide, KS-487, they successfully transported KS-133 across the blood-brain barrier. Their nanoparticle-based drug delivery system improved cognitive functions in mice, offering a new therapeutic strategy.
A new study shows GLP-1 receptor agonists increase pre-meal fullness by activating neurons in the dorsomedial hypothalamus. This mechanism helps prevent overeating, offering insights into obesity treatment. The research highlights how GLP-1 impacts food perception and hypothalamic responses to food cues, enhancing satiation before food intake.
New research shows people are more likely to accuse others of lying when AI makes the accusation first. This insight highlights the potential social impact of AI in lie detection and suggests caution for policymakers. The study found AI’s presence increased accusation rates and influenced behavior, despite people’s general reluctance to use AI lie detection […]
A new study documents the first case of Down syndrome in a Neandertal child named “Tina,” found in Spain. Despite severe hearing loss and vertigo, Tina survived to at least 6 years old, indicating she received extensive care from her group. This discovery highlights the Neandertals’ capacity for altruistic behavior.
COVID-19-induced cognitive impairment is linked to the protein IL-1β. Researchers found that vaccination can reduce brain inflammation and memory loss in rodent models. This suggests vaccines may lower the risk of long COVID brain fog. More research is needed to confirm these findings in humans.
The hypothalamus helps humans switch between survival behaviors like hunting and escaping. Researchers used AI-enhanced fMRI scans to analyze brain activity in 21 participants playing a survival game. They found distinct hypothalamus activity patterns linked to behavior switching. This discovery highlights the hypothalamus’s crucial role in survival strategies.
A new study reveals how depression affects brain activity in the basolateral amygdala (BLA) of rats. Using a microelectrode array, researchers found increased theta frequency activity in the BLA correlated with depressive behaviors. These findings could pave the way for targeted treatments for depression. The research highlights the potential of specific brain activity as a […]
A novel study uncovers how the protein Gephyrin aids in synapse formation, providing new insights into brain connectivity. The findings could help develop treatments for disorders like autism, epilepsy, and schizophrenia. Researchers used CRISPR-Cas9 to confirm Gephyrin’s role in autonomous synapse development. This breakthrough enhances understanding of synaptic mechanisms and potential therapeutic approaches.
A new study reveals the role of the molecule KIBRA in forming long-term memories. Researchers found that KIBRA acts as a “glue,” binding with the enzyme PKMzeta to strengthen and stabilize synapses, crucial for memory retention. This discovery could lead to new treatments for memory-related conditions. The findings confirm a long-standing hypothesis about memory storage […]
Researchers discovered how the brain controls sensitivity to threats, influencing escape behavior in mice. The study found that inhibitory neurons in the periaqueductal gray (PAG) regulate both the initiation and termination of escape.
