{"id":984,"date":"2024-09-30T13:21:00","date_gmt":"2024-09-30T13:21:00","guid":{"rendered":"http:\/\/sshop.me\/?p=984"},"modified":"2024-10-01T11:26:14","modified_gmt":"2024-10-01T11:26:14","slug":"prion-disease-mutations-impact-synapses-before-symptoms-appear","status":"publish","type":"post","link":"http:\/\/sshop.me\/index.php\/2024\/09\/30\/prion-disease-mutations-impact-synapses-before-symptoms-appear\/","title":{"rendered":"Prion Disease Mutations Impact Synapses Before Symptoms Appear"},"content":{"rendered":"<p><a href=\"https:\/\/neurosciencenews.com\/prion-disease-genetics-synapses-27724\/\" title=\"Prion Disease Mutations Impact Synapses Before Symptoms Appear\" rel=\"nofollow\"><img loading=\"lazy\" decoding=\"async\" width=\"1155\" height=\"770\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" class=\"webfeedsFeaturedVisual wp-post-image lazyload\" alt=\"This shows a brain.\" style=\"float: left;margin-right: 5px\" data-src=\"http:\/\/sshop.me\/wp-content\/uploads\/2024\/09\/prion-disease-mutations-neurosicence-1155x770-1.jpg\"><\/a>New research reveals that prion disease mutations can alter the structure of neuron synapses long before symptoms emerge. Scientists studied neurons derived from induced pluripotent stem cells (iPSCs) of patients with the E200K prion protein mutation, showing changes in neuron-to-neuron contact sites even in the absence of misfolded prion proteins. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>New research reveals that prion disease mutations can alter the structure of neuron synapses long before symptoms emerge. Scientists studied neurons derived from induced pluripotent stem cells (iPSCs) of patients with the E200K prion protein mutation, showing changes in neuron-to-neuron contact sites even in the absence of misfolded prion proteins.<\/p>\n","protected":false},"author":1,"featured_media":986,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-984","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-neuroscience"],"_links":{"self":[{"href":"http:\/\/sshop.me\/index.php\/wp-json\/wp\/v2\/posts\/984"}],"collection":[{"href":"http:\/\/sshop.me\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/sshop.me\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/sshop.me\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/sshop.me\/index.php\/wp-json\/wp\/v2\/comments?post=984"}],"version-history":[{"count":2,"href":"http:\/\/sshop.me\/index.php\/wp-json\/wp\/v2\/posts\/984\/revisions"}],"predecessor-version":[{"id":987,"href":"http:\/\/sshop.me\/index.php\/wp-json\/wp\/v2\/posts\/984\/revisions\/987"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/sshop.me\/index.php\/wp-json\/wp\/v2\/media\/986"}],"wp:attachment":[{"href":"http:\/\/sshop.me\/index.php\/wp-json\/wp\/v2\/media?parent=984"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/sshop.me\/index.php\/wp-json\/wp\/v2\/categories?post=984"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/sshop.me\/index.php\/wp-json\/wp\/v2\/tags?post=984"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}